Resumen de La producción de interferón gamma (IFN-y) se asocia a una menor concentración plasmática de proteína asociada a la gestación-1 y -2 (PAG-1 y PAG-2) en vacas lecheras gestantes crónicamente infectadas por neospora caninum
Beatriz Serrano Pérez, I. García, Carmen Nogareda Burch, S. Almeria, Fernando López Gatius
The objective of this work was to study the interaction between gamma interferon (IFN-y) production and plasma pregnancy-associated glycoprotein-1 (PAG-1) and -2 (PAG-2) concentrations throughout pregnancy in non-aborting chronically Neospora caninum-infected cows. Gamma interferon was detected at some point along the pregnancy in 9 (21%) of the 43 Neospora-seropositive cows. General lineal models (GLM) repeated measures ANOVA revealed significant effect of IFN-y production on plasma PAG-1 and PAG-2. IFN-y production was related to lower PAG-1 concentrations throughout gestation (P<0.05), respect to cows not producing IFN-y. Moreover, cows not producing IFN- showed significantly increased PAG-1 and PAG-2 concentrations at Day 120 of gestation (P<0.01 and P<0.05, respectively), respect to cows producing IFN-y. These results indicate that IFN- production has an effect on placental PAG secretion in non aborting Neospora-infected cows.
