Clinico-pathological and oncological differences between right and left-sided colon cancer (stages I-III): analysis of 950 cases

• Javier A. Cienfuegos ^[2] ; Jorge Baixauli ^[2] ; Jorge Arredondo ^[3] ; Carlos Pastor ^[1] ; Patricia Martínez Ortega ^[4] ; Gabriel Zozaya ^[2] ; Pablo Martí-Cruchaga ^[2] ; José Luis Hernández Lizoáin ^[2]
  1. [1] Fundación Jiménez Díaz

     Fundación Jiménez Díaz

     Madrid, España

     
  2. [2] Navarra University Clinic
  3. [3] Complejo Hospitalario de León
  4. [4] Centro Médico de Asturias. Oviedo

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• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 110, Nº. 3, 2018, págs. 138-144
• Idioma: inglés
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  • Purpose: The objective of the study was to analyze the clinico-pathological differences and the oncologic outcomes between right and left-sided colon cancer. Patients and methods: The patients cohort was identified from a prospective register of colon cancer, 950 patients underwent surgery (stages I, II and III), of which 431 had right-sided colon cancer and 519 had left-sided colon cancer. Results: More laparoscopic resections were performed (101 vs 191; p < 0.001) and operating times were longer (146 min vs 165 min; p < 0.001) in the left-sided colon group. Patients with right-sided colon cancer more frequently received transfusions (18.8% vs 11.3%; p < 0.001) and experienced a greater number of complications (28.5% vs 20.9%, p = 0.004), although severity and operative mortality were similar in both groups (1.2% vs 0.2%). Mucinous adenocarcinomas and undifferentiated tumors were more frequent in the right-sided group (12% vs 6.5%; p < 0.001). Early stage was predominant in the left-sided colon tumors (28.2% vs 34.5%, p = 0.02). There were no differences in disease-free survival (DFS) in stages I and II after a median follow-up of 103 months. However, a greater survival at five and ten years in left-sided, stage III tumors was observed, with a trend towards statistical significance (p = 0.06). No differences were found with regard to the patterns of recurrence. Conclusions: Right-sided colon cancer exhibits phenotypical differences with regard to left-sided colon cancer. In stage III disease, left-sided colon cancer has a greater survival with a trend towards statistical significance. Overall, tumor location is a variable that should be taken into consideration in clinical studies of colon cancer