Effects of different doses of resveratrol on body fat and serum parameters in rats fed a hypercaloric diet

• Autores: María Teresa Macarulla Arenaza, Goiuri Alberdi Aresti, S. Gómez, I. Tueros, Carlos Bald, Victor Manuel Rodríguez Rivera, José Alfredo Martínez Hernández, María Puy Portillo Baquedano
• Localización: Journal of physiology and biochemistry, ISSN-e 1877-8755, ISSN 1138-7548, Vol. 65, Nº. 4, 2009, págs. 369-376
• Idioma: inglés
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• Resumen

  • Recently resveratrol, a compound naturally occurring in various plants, has been proposed as a potential anti-obesity compound. The aim of the present work was to analyse the effects of different doses of resveratrol on body fat and serum parameters in rats. Thirty-two male Sprague-Dawley rats were randomly divided into four groups and fed on a hypercaloric diet for 6 weeks. The doses of trans-resveratrol used were 6, 30 and 60 mg/Kg body weight/d in RSV1, RSV2 and RSV3 groups respectively. The stability of resveratrol when added to the diet was evaluated. Blood samples were collected, and white adipose tissue from different anatomical locations, interscapular brown adipose tissue, gastrocnemious muscles and liver were weighed. Commercial kits were used to measure serum cholesterol, glucose, triacyglycerols and non-esterified fatty acids. While the lowest dose did not have a body fat reducing effect, the intermediate dose reduced all the white adipose depots. The highest dose significantly reduced mesenteric and subcutaneous depots but not epididymalan perirenal tissues. Altought the reduction in all the anatomical locations analysed was 19%in the RSV3 group, in the RSV2 group it was 24%. No significant differences among the experimental groups were found in brown adipose tissue, gastrocnemious muscle or liver weights. Serum parameters were not affected by resveratrol intake because no differences among the experimental groups were obeserved. These results suggest that resveratrol is a molecule with potential anti-obesity effect. The most effective of the three experimental doses was 30 mg/kg body weight/d.