Immunomodulation and metabolism: possible role of lactoferrin

• Autores: J. M. Moreno Navarrete
• Directores de la Tesis: José Manuel Fernández Real Lemos (dir. tes.)
• Lectura: En la Universitat de Girona ( España ) en 2011
• Idioma: catalán
• Tribunal Calificador de la Tesis: Antonio Zorzano Olarte (presid.), Victoria Catalán Goñi (secret.), Joan Vendrell Ortega (voc.), Maria Vilanova Brugués (voc.), Carmen Carretero Romay (voc.)
• Materias:
  • Ciencias de la vida
    • Biología molecular
  • Ciencias médicas
    • Medicina interna
      • Endocrinología
• Enlaces
  • Tesis en acceso abierto en: TDX
• Resumen

  • To gain insight in the relationship between innate immune system and metabolic disease, we aimed to investigate the effects of lactoferrin in obesity-related metabolic disturbances. Circulating lactoferrin concentration was significantly decreased in subjects with altered glucose tolerance (AGT) and associated negatively with obesity-related metabolic disturbances. The SNPs-induced aminoacidic changes in lactoferrin N-terminus region were associated with a low atherogenic lipid profile. Lactoferrin production in neutrophils decreased significatively in aging, chronic low-grade inflammation and type 2 diabetes. In vitro, lactoferrin increased insulin signaling pathway, even under insulin resistance conditions and displayed dual effects on adipogenesis (antiadipogenic in 3T3-L1 and adipogenic in human adipocytes). In conclusion, lactoferrin might play a potential protective role against insulin resistance and obesity related metabolic disturbances.