Study of biomolecular self-assembly and host-guest association using spectroscopic and microscopic techniques

• Autores: Sara Illodo Brea
• Directores de la Tesis: Maria de la Merced Novo Rodriguez (dir. tes.), Flor Rodríguez Prieto (dir. tes.)
• Lectura: En la Universidade de Santiago de Compostela ( España ) en 2024
• Idioma: español
• Tribunal Calificador de la Tesis: Manuel José Prieto Montt (presid.), Ana María Ríos Rodríguez (secret.), Juan Carlos Penedo Esteiro (voc.)
• Programa de doctorado: Programa de Doctorado en Ciencia y Tecnología Química por la Universidad de Santiago de Compostela y la Universidad de Vigo
• Materias:
  • Química
    • Química analítica
      • Espectroscopia de emisión
      • Microscopia
    • Bioquímica
      • Biología molecular
• Enlaces
  • Tesis en acceso abierto en: MINERVA
• Resumen

  • Neurodegenerative diseases represent a major health problem. Biomolecules involved in these disorders are essential for life, but the misregulation of their interactions can lead to severe damage it. Thus, understanding these biomolecular interactions is vital for developing effective treatments. In this thesis, we study the self-assembly and binding processes of biomolecules like G-quadruplexes, amyloid peptides, and blood plasma proteins, which are thought to be involved in Alzheimers disease. Using microscopic and spectroscopic techniques, we study the mechanisms behind the selfassembly of G-Quadruplexes, the aggregation of amyloid peptides and the host-guest association of blood plasma proteins with fluorescence probes.