Merging Inline NMR Monitoring and Flow Chemistry in the Undergraduate Organic Chemistry LaboratoryC

• Bradley Graeme Welch ^[1] ; David Cantillo ^[1]
  1. [1] University of Queensland

     University of Queensland

     Australia

     
• Localización: Journal of chemical education, ISSN 0021-9584, Vol. 101, Nº 8, 2024, págs. 3459-3465
• Idioma: inglés
• Texto completo no disponible (Saber más ...)
• Resumen

  • The implementation of process analytical technologies is rapidly growing in the chemical industry as data-rich experimentation becomes more relevant. Such tools are often incorThe implementation of process analytical technologies is rapidly growing in the chemical industry as data-rich experimentation becomes more relevant. Such tools are often incorporated into flow reactors, where data collection is particularly relevant in process research. A laboratory project devised for third-year undergraduate chemistry students that combines continuous flow chemistry with inline nuclear magnetic resonance (NMR) monitoring was developed and evaluated. The student project provides hands-on experience in basic flow chemistry tools and process monitoring strategies via the generation of real-time reaction data using a benchtop NMR spectrometer in flow mode. The project also includes a second synthetic step in batch mode and structure elucidation using 1D and 2D NMR spectroscopy.porated into flow reactors, where data collection is particularly relevant in process research. A laboratory project devised for third-year undergraduate chemistry students that combines continuous flow chemistry with inline nuclear magnetic resonance (NMR) monitoring was developed and evaluated. The student project provides hands-on experience in basic flow chemistry tools and process monitoring strategies via the generation of real-time reaction data using a benchtop NMR spectrometer in flow mode. The project also includes a second synthetic step in batch mode and structure elucidation using 1D and 2D NMR spectroscopy.