Resumen de Efecto de la midodrina en la hipotensión sintomática en hemodiálisis
Alejandro Cotera, Miriam Alvo, María Eugenia Sanhueza, Leticia Elgueta, Juan Pablo Gormaz B, Carlos Ibáñez B, Cristián Cuadra C
Background: Hypotension occurs in 20% of hemodialysis procedures. Aim: To study the effects of midodrine on hypotension during hemodialysis. Patients and methods: Ten patients on chronic hemodialysis and with a history of hypotension during the procedure, were studied. They received midodrine 10 mg per os or placebo during 5 dialytic procedures each, in a double blind cross over design. Results: Blood pressure levels prior to dialysis were similar during the midodrine or placebo administration periods. During dialysis, systolic blood pressure fell 19.3±28 mmHg with midodrine and 23.4±28 mmHg with placebo. Diastolic blood pressure fell 7.3±11.5 mmHg with midodrine and 11.1±12 mmHg with placebo. The reduction in median arterial pressure was also less pronounced with midodrine. Conclusions: Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension (Rev Méd Chile 2002; 130: 1009-13)
