Efecto de la midodrina en la hipotensión sintomática en hemodiálisis
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Alejandro Cotera F [1] ; Miriam Alvo A [1] ; María Eugenia Sanhueza V [1] ; Leticia Elgueta S [1] ; Juan Pablo Gormaz B [1] ; Carlos Ibáñez B [1] ; Cristián Cuadra C [1]
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[1] Universidad de Chile
Universidad de Chile
Santiago, Chile
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- Localización: Revista Médica de Chile, ISSN-e 0034-9887, Vol. 130, Nº. 9, 2002, págs. 1009-1013
- Idioma: español
- Títulos paralelos:
- Effects of midodrine on orthostatic hypotension during hemodialysis
- Enlaces
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Resumen
Background: Hypotension occurs in 20% of hemodialysis procedures. Aim: To study the effects of midodrine on hypotension during hemodialysis. Patients and methods: Ten patients on chronic hemodialysis and with a history of hypotension during the procedure, were studied. They received midodrine 10 mg per os or placebo during 5 dialytic procedures each, in a double blind cross over design. Results: Blood pressure levels prior to dialysis were similar during the midodrine or placebo administration periods. During dialysis, systolic blood pressure fell 19.3±28 mmHg with midodrine and 23.4±28 mmHg with placebo. Diastolic blood pressure fell 7.3±11.5 mmHg with midodrine and 11.1±12 mmHg with placebo. The reduction in median arterial pressure was also less pronounced with midodrine. Conclusions: Midodrine lessens the fall in arterial pressure during hemodialysis, in patients with symptomatic hypotension (Rev Méd Chile 2002; 130: 1009-13)
