Resumen de Cytotoxic constituents from the root wood of formosan michelia compressa

Chia-yuan Liu, Yang-wen Chen, Ming-jen Cheng, Shoiw-ju Lee, Mohamed H Abd El-razek, Wen-hsiung Chang, Yu-Jen Chen, Ih-Sheng Chen

• The methanolic extract of the root wood of Michelia compressa (Maxim.) Sargent showed cytotoxicity against MCF-7, NCI-H460 and SF-268 cancer cell lines. Bioassay-guided fractionation of the chloroform-soluble layer led to the isolation of costunohde and liriodenine with cytotoxic activities, along with the isolation of twenty-seven known compounds. The active costunohde existed as major constituent in this study.