Cytotoxic constituents from the root wood of formosan michelia compressa

• CHIA-YUAN LIU ^[1] ; YANG-WEN CHEN ^[2] ; MING-JEN CHENG ^[2] ; SHOIW-JU LEE ^[3] ; MOHAMED H ABD EL-RAZEK ^[2] ; WEN-HSIUNG CHANG ^[1] ; YU-JEN CHEN ^[1] ; IH-SHENG CHEN ^[2]
  1. [1] Mackay Memorial Hospital

     Mackay Memorial Hospital

     Taiwán

     
  2. [2] Kaohsiung Medical University

     Kaohsiung Medical University

     Taiwán

     
  3. [3] National Health Research Institutes

     National Health Research Institutes

     Taiwán

     

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 53, Nº. 2, 2008, págs. 1523-1524
• Idioma: inglés
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  • The methanolic extract of the root wood of Michelia compressa (Maxim.) Sargent showed cytotoxicity against MCF-7, NCI-H460 and SF-268 cancer cell lines. Bioassay-guided fractionation of the chloroform-soluble layer led to the isolation of costunohde and liriodenine with cytotoxic activities, along with the isolation of twenty-seven known compounds. The active costunohde existed as major constituent in this study.