Resumen de Synthesis of conformationally restricted n-{4-[4-(4,7-dimethoxy-benzo[b]thiophene-2-carbonyl)-1-piperazinyl]-phenyl}-arylcarboxamides potential ligands with 5-ht1a binding affinity

Hernán Pessoa-mahana, Christian González L, Ramiro Araya-maturana, Claudio Sáitz Barría, D Pessoa-mahana

• New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminopheny1)-4-[(4,7-dimethoxy-1-benzothien-2-y1)carbonyl] piperazine (6) with a series of substituted aroyl chlorides.