Synthesis of conformationally restricted n-{4-[4-(4,7-dimethoxy-benzo[b]thiophene-2-carbonyl)-1-piperazinyl]-phenyl}-arylcarboxamides potential ligands with 5-ht1a binding affinity

• HERNÁN PESSOA-MAHANA ^[1] ; CHRISTIAN GONZÁLEZ L ^[1] ; RAMIRO ARAYA-MATURANA ^[1] ; CLAUDIO SAITZ B ^[1] ; C. DAVID PESSOA-MAHANA ^[1]
  1. [1] Universidad de Chile

     Universidad de Chile

     Santiago, Chile

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 54, Nº. 2, 2009, págs. 147-150
• Idioma: inglés
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• Resumen

  • New benzothiophene arylpiperazine derivatives 7 (a-f) were synthesized as potential serotoninergic agents with 5-HT1A receptor affinity. Preparation of the derivatives was performed by reaction of 1-(4-aminopheny1)-4-[(4,7-dimethoxy-1-benzothien-2-y1)carbonyl] piperazine (6) with a series of substituted aroyl chlorides.