Resumen de Synthesis, characterization and antihypertensive activity of some new substituted pyridazine derivatives

Ravinesh Mishra, Anees A Siddiqui, Asif Husain, Mohd. Rashid, Atish Prakash, Mukul Tailang, Munesh Kumari, Neeti Srivastava

• Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e and 4i showed appreciable antihypertensive activity.