Synthesis, characterization and antihypertensive activity of some new substituted pyridazine derivatives

• RAVINESH MISHRA ^[1] ; ANEES A SIDDIQUI ^[2] ; ASIF HUSAIN ^[2] ; MOHD RASHID ^[2] ; ATISH PRAKASH ^[1] ; MUKUL TAILANG ^[1] ; MUNEESH KUMAR ^[3] ; NEETI SRIVASTAVA ^[3]
  1. [1] University of Emerging Science & Technology Institute of Pharmacy & Emerging Sciences
  2. [2] Jamia Hamdard Faculty of Pharmacy Department of Pharmaceutical Chemistry
  3. [3] NKBR College of Pharmacy & Research Centre

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• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 56, Nº. 4, 2011, págs. 856-859
• Idioma: inglés
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  • Some new 6-(substituted phenyl)-2-(4-substituted phenyl-5-thioxo-4,5-dihydro-1H-1,2,4-triazol-3-yl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by a sequence of reactions starting from respective aryl hydrocarbons. The final compounds (4a-i) were screened for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 4e and 4i showed appreciable antihypertensive activity.