Resumen de A comparative study of thermodynamic properties of structurally related phenothiazine drugs in aqueous solution

Muhammad Usman, Muhammad Arif Cheema, Abbas Khan, Zahoor Hussain Farooqi, Víctor Mosquera Tallón, Mohammad Siddiq

• Association characteristics of amphiphilic phenothiazine drugs Fluphenazine and Trifluperazine dihydrochloride in water have been examined and their thermodynamic parameters have been calculated using conductometry. The electrical conductivity was measured as a function of concentration at various temperatures and cmc was calculated in the temperature range of 20-50°C. Thermodynamic parameters i.e. standard free energy of micellization, ΔG° , standard enthalpy of micellization, ΔH°m and standard entropy of micellization, ASm were calculated from cmc value using closed association model.