A comparative study of thermodynamic properties of structurally related phenothiazine drugs in aqueous solution

MUHAMMAD USMAN ^[3] ; MUHAMMAD ARIF CHEEMA ^[4] ; ABBAS KHAN ^[5] ; ZAHOOR HUSSAIN FAROOQI ^[6] ; VICTOR MOSQUERA ^[1] ; MOHAMMAD SIDDIQ ^[2]
1. [1] Universidade de Santiago de Compostela
  
  Universidade de Santiago de Compostela
  
  Santiago de Compostela, España
2. [2] Quaid-i-Azam University
  
  Quaid-i-Azam University
  
  Pakistán
3. [3] Government College University Department of Chemistry
4. [4] Government College Gujranwala Department of Chemistry
5. [5] Abdul Wali Khan University Department of Chemistry
6. [6] University of the Punjab Institute of Chemistry
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Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 3, 2013, págs. 1842-1845
Idioma: inglés
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Resumen
- Association characteristics of amphiphilic phenothiazine drugs Fluphenazine and Trifluperazine dihydrochloride in water have been examined and their thermodynamic parameters have been calculated using conductometry. The electrical conductivity was measured as a function of concentration at various temperatures and cmc was calculated in the temperature range of 20-50°C. Thermodynamic parameters i.e. standard free energy of micellization, ΔG° , standard enthalpy of micellization, ΔH°m and standard entropy of micellization, ASm were calculated from cmc value using closed association model.