Resumen de Synthesis and in vitro antibacterial activity of four novel pleuromutilin derivatives
Youzhi Tang, Jian Luo, Xiaojie Chen, Bo Wang, Xiangguang Shen, Jianhua Liu
Four novel pleuromutilin derivatives with butyl amine group in the C-14 side-chain were designed, synthesized and confirmed by FT-IR, ¹H-NMR and HR-MS. The results of antibacterial activity showed that the antibacterial activity of pleuromutilin derivatives could be affected by the steric hindrance of their C-14 side-chain.
