Synthesis and in vitro antibacterial activity of four novel pleuromutilin derivatives

• YOUZHI TANG ^[1] ; JIAN LUO ^[1] ; XIAOJIE CHEN ^[1] ; BO WANG ^[1] ; XIANGGUANG SHEN ^[1] ; JIANHUA LIU ^[1]
  1. [1] South China Agricultural University

     South China Agricultural University

     China

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 58, Nº. 1, 2013, págs. 1537-1540
• Idioma: inglés
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• Resumen

  • Four novel pleuromutilin derivatives with butyl amine group in the C-14 side-chain were designed, synthesized and confirmed by FT-IR, ¹H-NMR and HR-MS. The results of antibacterial activity showed that the antibacterial activity of pleuromutilin derivatives could be affected by the steric hindrance of their C-14 side-chain.