Resumen de A convenient synthesis and cytotoxic activity of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes under solvent-free conditions

Carlos Jonnatan Pimentel Barros, Zilyane Cardoso de Souza, Jucleiton José Rufino de Freitas, Paulo Bruno Norberto da Silva, Gardenia Carmen Gadelha Militão, Teresinha Gonçalves da Silva, Juliano Carlo Rufino de Freitas, João Rufino Freitas Filho

• The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compounds were elucidated using IR, ¹H and 13C NMR spectroscopy and elemental analysis and their antiproliferative activities was evaluated against three different human cell lines.