A convenient synthesis and cytotoxic activity of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes under solvent-free conditions

• CARLOS JONNATAN PIMENTEL BARROS ^[1] ; ZILYANE CARDOSO DE SOUZA ^[1] ; JUCLEITON JOSÉ RUFINO DE FREITAS ^[1] ; PAULO BRUNO NORBERTO DA SILVA ^[2] ; GARDENIA CARMEN GADELHA MILITÃO ^[2] ; TERESINHA GONÇALVES DA SILVA ^[2] ; JULIANO CARLO RUFINO FREITAS ^[1] ; JOÃO RUFINO DE FREITAS FILHO ^[1]
  1. [1] Universidade Federal Rural de Pernambuco

     Universidade Federal Rural de Pernambuco

     Brasil

     
  2. [2] Universidade Federal de Pernambuco

     Universidade Federal de Pernambuco

     Brasil

     
• Localización: Journal of the Chilean Chemical Society (Boletín de la Sociedad Chilena de Química), ISSN-e 0717-6309, ISSN 0366-1644, Vol. 59, Nº. 1, 2014, págs. 2359-2362
• Idioma: inglés
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• Resumen

  • The synthesis of 3-aryl-5-pentyl-1,2,4-oxadiazoles from carboxylic acid esters and arylamidoximes in the presence of potassium carbonate is described. The reaction was carried out in a microwave oven without any solvent in much shorter time and in good yields. The structures of the synthesized compounds were elucidated using IR, ¹H and 13C NMR spectroscopy and elemental analysis and their antiproliferative activities was evaluated against three different human cell lines.