Resumen de Gingival neoplasms: a multicenter collaborative study of 888 patients in Brazil
Éder Gerardo Santos-Leite, Brendo Vinícius Rodrigues Louredo, Lucas-Lacerda de Souza, Hélder-Antônio Rebelo-Pontes, Flávia Sirotheau Corrêa Pontes, Jean Nunes dos Santos, Águida Cristina Gomes Henriques, Jurema Freire Lisboa de Castro, Elaine Judite de Amorim Carvalho, Augusto-César-Leal-da Silva Leonel, Raylane Farias de Albuquerque, Thayanne Oliveira de Freitas Gonçalves, Aline Corrêa-Abrahão, Michelle Agostini, Mário José Romañach, Vinicius C. Carrard, Manoela D. Martins, Teresa-Cristina-Ribeiro-Bartholomeu dos-Santos, Fábio-Ramôa Pires, Alan Roger Santos Silva, Márcio Ajudarte Lopes, Pablo Agustín Vargas, Danyel Elias da Cruz Perez
To evaluate the prevalence and clinicopathological features of a large series of gingival neoplasms in Brazil.
All gingival benign and malignant neoplasms were retrieved from the records of six Oral Pathology Services in Brazil, during a 41-year period. Clinical and demographic data, clinical diagnosis, and histopathological data were collected from the patients' clinical charts. For statistical analysis, the chi-square, median test of independent samples and the U Mann-Whitney tests were used, considering a significance of 5%.
From 100,026 oral lesions, 888 (0.9%) were gingival neoplasms. There were 496 (55.9%) males, with a mean age of 54.2 years. Most cases (70.3%) were malignant neoplasms. Nodules (46.2%) and ulcers (38.9%) were the most common clinical appearance for benign and malignant neoplasms, respectively. Squamous cell carcinoma (55.6%) was the most common gingival neoplasm, followed by squamous cell papilloma (19.6%). In 69 (11.1%) malignant neoplasms, the lesions were clinically considered to be inflammatory or of infectious origin. Malignant neoplasms were more common in older men, appeared with larger size, and with a time of complaint shorter than benign neoplasms (p<0.001).
Benign and malignant tumors may appear as nodules in gingival tissue. In addition, malignant neoplasms, especially squamous cell carcinoma, should be considered in the differential diagnosis of persistent single gingival ulcers.
