Mantenimiento de la diversidad genética mediante el parentesco molecular: Influencia del censo efectivo y la densidad de SNPS

• F. Gómez Romano ^[1] ; B. Villanueva ^[1] ; M.A.R. de Cara ^[1] ; J. Fernández ^[1]
  1. [1] INIA
• Localización: XV Jornadas sobre Producción Animal: 14 y 15 de mayo de 2013, Zaragoza / Jorge Hugo Calvo Lacosta (aut.), Isabel Casasús Pueyo (aut.), Margalida Joy Torrens (aut.), Javier Álvarez Rodríguez (aut.), Luis Varona Aguado (aut.), Begoña Panea Doblado (aut.), Carlos Calvete Margolles (aut.), Joaquín Balcells Teres (aut.), Vol. 2, 2013, ISBN 978-84-695-7684-7, págs. 589-591
• Idioma: español
• Títulos paralelos:
  • Maintaining genetic diversity using molecular coancestry: The effect of marker density and effective population size
• Enlaces
  • Texto Completo Libro  1 (pdf)   2 (pdf) 
• Resumen

  • The most efficient method for maintaining genetic diversity in populations under conservation programmes is to optimise, for each potential parent, the number of offspring left to the next generation that minimise global coancestry. Recent studies have shown that optimising contributions based on coancestry calculated from a large number of SNP markers could maintain higher levels of diversity than optimising contributions based on genealogical data. In this study we investigate how SNP density and effective population size impact the effectiveness of using molecular coancestry for maintaining diversity. The performance of molecular coancestry equalised the performance of genealogical coancestry when the SNP density was about 3 times the effective population size. However, the increasing SNP density had diminishing returns in maintained diversity. Most SNP chips already available for farm animals have enough density to allow marker coancestry to outperform genealogical coancestry in maintaining diversity in conservation programmes. The decreasing costs of developing SNP chips will make these densities to be feasible in a short-term horizon.