Estimas genómicas de parentesco y consanguinidad en una antigua piara consanguínea de cerdo ibérico

• M. Saura ^[1] ; A. Fernández ^[1] ; M.C. Rodríguez ^[1] ; M.A. Toro ; C. Barragán ^[1] ; A.I. Fernández ^[1] ; B. Villanueva ^[1]
  1. [1] INIA
• Localización: XV Jornadas sobre Producción Animal: 14 y 15 de mayo de 2013, Zaragoza / Jorge Hugo Calvo Lacosta (aut.), Isabel Casasús Pueyo (aut.), Margalida Joy Torrens (aut.), Javier Álvarez Rodríguez (aut.), Luis Varona Aguado (aut.), Begoña Panea Doblado (aut.), Carlos Calvete Margolles (aut.), Joaquim Barcells Teres (aut.), Vol. 2, 2013, ISBN 978-84-695-7684-7, págs. 601-603
• Idioma: español
• Títulos paralelos:
  • Genome-wide estimates of coancestry and inbreeding in a closed herd of ancient iberian pigs
• Enlaces
  • Texto Completo Libro  1 (pdf)   2 (pdf) 
• Resumen

  • Maintaining genetic variation and controlling the increase in inbreeding are crucial requirements in animal conservation programs. As a general rule, the most widely accepted strategy to implement in conservation programs is to maximize the effective population size by minimizing the global coancestry obtained from the pedigree. When genealogical information is absent, microsatellites have been traditionally the markers of choice to characterize genetic variation, with questionable results. The development of highthroughput genotyping techniques states the necessity of reviewing the paradigm that genealogy is the best parameter to measure genetic diversity. In this study the Illumina PorcineSNP60 BeadChip was used to obtain genome-wide estimates of rates of coancestry and inbreeding and effective population size for an ancient strain of Iberian pigs which is now in serious danger of extinction. These estimates were compared with those obtained from microsatellite and from pedigree data. Estimates of coancestry and inbreeding computed from the SNP chip were strongly correlated with genealogical estimates and these correlations were substantially higher than those between microsatellite and genealogical coefficients. Molecular coancestry computed from SNP information was a better predictor of genealogical coancestry than coancestry computed from microsatellites. Our results indicate that genome-wide information represents a useful alternative to genealogical information for measuring and maintaining genetic diversity.