The study integrated digital technologies (GeoGebra) tools to test the significance and success of employing 4T anthropological moments of didactical praxeologies in the teaching and learning of conceptual structures in the parabola. The experimental methodology explored mixed methods concurrent convergent design involving the GeoGebra to collect and analyze quantitative data with quasi-experimental tests and content analysis with an interview guide to collect and analyze qualitative data from thirty three groups of preservice teachers of the University of Education, Winneba, Ghana. The findings of both the quantitative and qualitative results showed that the 4T models of anthropological moments of didactical praxeologies with the GeoGebra achieved higher significant improvements as compared to the conventional methods and were adjudged most successful models for didactical praxeologies in the teaching and learning of conceptual structures in the parabola. It was therefore, concluded that the 4T models be adopted as main instructional models in the teaching and learning of conceptual structures in multiple mathematics domains.
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