High expression of NDRG3 correlates with poor prognosis in gastric cancer patients

• Yun Liu ^[1] ; Jinxuan Xia ^[2] ; Yong Zhou ^[1] ; Shihe Shao ^[1]
  1. [1] Jiangsu University

     Jiangsu University

     China

     
  2. [2] Zhenjiang Mental Health Center. Jiangsu, China
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 113, Nº. 7, 2021, págs. 524-528
• Idioma: inglés
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• Resumen

  • Introduction: N-myc downstream-regulated gene 3 (NDRG3) is an important member of the NDRG family and is linked with malignant tumors. However, the relationship between NDRG3 and gastric cancer (GC) is vague. Material and methods: Western blot, qRT-PCR and immunohistochemistry (IHC) detected the expression of NDRG3 in GC cell lines and GC tissues; public databases were used to analyze NDRG3 in GC patients and the association with EBV infection. Results: NDRG3 was up-regulated in GC cell lines and tissues. IHC data suggested that NDRG3 was correlated with histologic grade (p = 0.006) and is associated with patient survival. Discussion: thus, NDRG3 may be a novel predictor of GC prognosis