Using genome-wide mapping in the mouse to identify genes that influence drug response

• Autores: James W. Watters, Howard McLeod
• Localización: Trends in pharmacological sciences, ISSN 0165-6147, Vol. 24, Nº. 2 (February), 2003, págs. 55-57
• Idioma: inglés
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• Resumen

  • Differential drug response is most often likely to be a complex trait, controlled by the combined influences of multiple genes and environmental influences. As a result of theoretical and technical limitations, to date, most clinically useful pharmacogenomic studies in humans have been limited to a small number of candidate genes that have a relatively major impact on drug response. Here, the problems involved in identifying genes that underlie drug response in humans are discussed and the power of mouse genetics as a tool for pharmacogenomic discovery is highlighted.