Interfering with leukocyte rolling ¿ a promising therapeutic approach in inflammatory skin disorders?

• Autores: Michael P. Schön, Wolf-H. Boehncke
• Localización: Trends in pharmacological sciences, ISSN 0165-6147, Vol. 24, Nº. 2 (February), 2003, págs. 49-51
• Idioma: inglés
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• Resumen

  • Many novel anti-inflammatory compounds have been derived from research tools designed to better understand the complex process of leukocyte extravasation at sites of inflammation. Given that selectin-mediated rolling is the crucial initial step of leukocyte localization to the skin, specific interference with this mechanism is a particularly attractive target to treat cutaneous inflammation. Recently, several exciting advances have been reported aimed at selective interference with specific target molecules crucially involved in leukocyte rolling