Resumen de MIB1 proliferation index in breast infiltrating carcinoma: Comparison with other proliferative markers and association with new biological prognostic factors
María Carmen González Vela, M.F. Garijo, F. Fernández, José Fernando Val Bernal
Aims: In breast invasive carcinoma our objectives were I) to compare cellular proliferation determined by MIBI index with S-phase fraction (SPF) assessed by flow cytometry and with mitotic index, and II) to examine the association of MIBI index with classical and with new biological prognostic factors [bcl2, p53, c-erbB-2 and cathepsin D (CD)]. Methods and results: From 102 cases of breast invasive carcinoma, 5,um thick serial sections were cut from formalin-fixed, paraffin-embedded tissue blocks, and processed for detection of CD, c-erbB-2, p53, bcl-2, Ki-67 antigen MIB-l and estrogen receptors (ER) and progesterone receptors (PR). SPF was measured by flow cytometry in fresh-frozen tissue samples taken from the carcinoma in each patient. MIBI index was correlated with SPF (rho=0.45, p
