Resumen de Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance
Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies.
Here. we summarize the evidence supporting a critical role for the co-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptormediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy.
Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance.
