Differential signaling through the T cell receptor: from biochemistry to transplantation tolerance

• Madrenas, J. ^[1] ; Lazarovits, A. I. ^[1]
  1. [1] University of Western Ontario

     University of Western Ontario

     Canadá

     
• Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 13, Nº. 1, 1998, págs. 221-229
• Idioma: inglés
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• Resumen

  • Recent advances in our understanding of the structural nature of T cell activation and signal transduction from the T cell receptor for antigen make possible the development of new tolerogenic strategies.

    Here. we summarize the evidence supporting a critical role for the co-receptor molecule (CD4 or CD8) and CD45 in determining the pattern of T cell receptormediated signaling. The consequences of this differential signaling can range from T cell proliferation and cytokine production to the establishment of a state of proliferative unresponsiveness known as T cell anergy.

    Inducing T cell anergy can be an alternative approach for the establishment of transplantation tolerance.