Exploiting the Natural Diversity of RhlA Acyltransferases for the Synthesis of the Rhamnolipid Precursor 3-(3-Hydroxyalkanoyloxy)Alkanoic Acid

• Andrea Germer ^[1] ; Till Tiso ^[1] ; Conrad Müller ^[1] ; Beate Behrens ^[2] ; Christian Vosse ^[2] ; Karen Scholz ^[2] ; Matti Froning ^[2] ; Heiko Hayen ^[2] ; Lars M. Blank ^[1]
  1. [1] Rheinisch-Westfälische Technische Hochschule Aachen University

     Rheinisch-Westfälische Technische Hochschule Aachen University

     Städteregion Aachen, Alemania

     
  2. [2] University of Münster

     University of Münster

     Kreisfreie Stadt Münster, Alemania

     
• Localización: Applied and Environmental Microbiology, ISSN 0099-2240, Vol. 86, Nº 6, 2020
• Idioma: inglés
• Enlaces
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• Resumen

  • The RhlA specificity explains the observed differences in 3-(3-hydroxyalkanoyloxy)alkanoic acid (HAA) congeners. Whole-cell catalysts can now be designed for the synthesis of different congener mixtures of HAAs and rhamnolipids, thereby contributing to the envisaged synthesis of designer HAAs.