Resumen de Mechanobiology of protein droplets: force arises from disorder

Timothy J. Welsh, Yi Shen, Aviad Levin, Tuomas P. J. Knowles

• The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et al., 2018 , Shin et al., 2018 ). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.