Mechanobiology of protein droplets: force arises from disorder

• Timothy J. Welsh ^[1] ; Yi Shen ^[1] ; Aviad Levin ^[1] ; Tuomas P. J. Knowles ^[1]
  1. [1] University of Cambridge

     University of Cambridge

     Cambridge District, Reino Unido

     
• Localización: Cell, ISSN 0092-8674, Vol. 175, Nº. 6, 2018, págs. 1457-1460
• Idioma: inglés
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• Resumen

  • The use of optogenetic approaches has revealed new roles for intracellular protein condensates described in two papers in this issue of Cell (Bracha et al., 2018 , Shin et al., 2018 ). These results show that growing condensates are able to exert mechanical forces resulting in chromatin rearrangement, establishing a new role for liquid-liquid phase separation in the mechanobiology of the cell.