Resumen de Synthesis of Green Fluorescent Protein Chromophore Analogues for Interdisciplinary Learning for High School Students
Shiho Numanoi, Makiko Hashimoto, Sonoko Hashimoto, Katsunori Kazawa, Ryo Sakaguchi, Kota Miyata, Rino Iwakami, Takahiro Mitome, Shintaro Anju, Ryo Shinotsuka, Toru Oba
Interdisciplinary outreach activities with easy-to-implement experiments have been developed to enhance high school students’ interest in chemistry and their inquisitive minds with active learning strategies. The synthesis of a model chromophore of the green fluorescent protein was employed as a key motif. Students simply enjoyed observing changes in the substances as well as witnessing a variety of fluorescent emissions. They gradually realized the importance of molecular design in the understanding and development of chemistry, biology, physics, and medicine.
