Resumen de A “counter-enhancer” in tumor suppression

Francesco P. Marchese, Maite Huarte Martínez

• The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.