A “counter-enhancer” in tumor suppression

• Autores: Francesco P. Marchese, Maite Huarte Martínez
• Localización: Cell, ISSN 0092-8674, Vol. 173, Nº. 6, 2018, págs. 1318-1319
• Idioma: inglés
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• Resumen

  • The role of the noncoding genome in cancer biology is continually expanding. Cho et al. reveal a new and unexpected mechanism for the regulation of MYC expression mediated by the promoter sequence of its neighbor gene PVT1. This DNA element acts as a promoter-enhancer competitor and a candidate tumor suppressor.