Resumen de Using metagenomics to characterize an expanding virosphere

Yong-Zhen Zhang, Mang Shi, Edward C. Holmes

• We know less about viruses than any other lifeform. Fortunately, metagenomics has led to a massive expansion in the known diversity of the virosphere. Here, we discuss how metagenomics has changed our understanding of RNA viruses and present some of the remaining challenges, including characterization of the “dark matter” of divergent viral genomes.