EUS-FNA cytological material from pancreatic lesions: the expression of cathepsins and its predictive value of malignancy

• Manuela Roger ^[1] ; Juan Martínez ^[1] ; Gloria Peiró ^[1] ; Jose Ramón Aparicio ^[1] ; Francisco Ruiz ^[1] ; Luís Compañy ^[1] ; Juan Antonio Casellas ^[1]
  1. [1] Hospital General Universitario de Alicante

     Hospital General Universitario de Alicante

     Alicante, España

     
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 110, Nº. 7, 2018, págs. 446-450
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Aims: To assess the expression of cathepsins in pancreatic samples obtained by endoscopic ultrasonography and fine needle aspiration (EUS-FNA) and to investigate their relationship with the staging of the pancreatic ductal adenocarcinoma (PDAC). Methods: We prospectively included patients with solid pancreatic masses, in which EUS-FNA were performed. Cathepsins B, L, S and H expression was determined in FNA samples. Results: Seventeen FNA were performed. All cytological material was from PDAC. Expression of cathepsins was predominantly low (B 65%, L 23%, S 76%, and H 41%). We found no correlation between the expression levels and the extension of the neoplasm. Conclusion: Expression of cathepsins in the cytological material of PDAC is diverse but still poor to be useful in the pre-operative diagnosis. There is no correlation between the expression levels of cathepsins and the extension of the PDAC