Enteral nutrition is associated with a decreased risk of surgical intervention in Crohn’s disease patients with spontaneous intra-abdominal abscess

• Xiao-Bin Zheng ^[1] ; Xiang Peng ^[1] ; Xiao-Yu Xie ^[1] ; Lei Lian ^[1] ; Xian-Rui Wu ^[1] ; Jian-Cong Hu ^[1] ; Xiao-Wen He ^[1] ; Jia Ke ^[1] ; Yu-Feng Chen ^[1] ; Min Zhi ^[1] ; Xiao-Jian Wu ^[1] ; Xiao-Sheng He ^[1] ; Ping Lan ^[1]
  1. [1] Sixth Affiliated Hospital of Sun Yat-sen University

     Sixth Affiliated Hospital of Sun Yat-sen University

     China

     
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 109, Nº. 12, 2017, págs. 834-842
• Idioma: inglés
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• Resumen

  • Background: The impact of enteral nutrition (EN) on surgical risk in Crohn’s disease (CD) patients suffering from spontaneous intra-abdominal abscess (IAA) was evaluated. Methods: CD patients diagnosed with spontaneous IAA from 2008 to 2015 were included in the study. The impact of EN on surgical risk was evaluated using both univariate and multivariate analyses. Results: A total of 87 patients were enrolled, 66 (75.9%) were male. The mean age at the development of an abscess was 30.2 ± 10.1 years and the median duration of illness from CD diagnosis until the development of an abscess was three (2-6) years. After a median follow-up of 1.9 (1.1-2.9) years, surgical intervention was performed in 42 patients (48.3%). Patients treated with EN were less likely to require surgical intervention (26.1% vs 56.3%, p = 0.01). Multivariate analysis showed that EN was an independent protective factor for the risk of surgery with a hazard ratio of 0.27 (95% confidence interval: 0.11-0.65, p = 0.004) after adjusting for abdominal pain, history of abdominal surgery, concomitant intestinal stenosis and prior use of antibiotics within three months. Conclusions: Surgical intervention is common for CD patients with IAA. Appropriate application of EN may help obviate the need for surgical treatment