Study of the expression of cathepsins in histological material from pancreatic lesions

• Juan F. Martínez ^[1] ; José Ramón Aparicio ^[1] ; Gloria Peiró ^[1] ; Antonio Cabezas ^[1] ; Manuela Roger ^[1] ; Francisco Ruiz ^[1] ; Luís Compañy ^[1] ; Juan Antonio Casellas ^[1]
  1. [1] Hospital General Universitario de Alicante

     Hospital General Universitario de Alicante

     Alicante, España

     
• Localización: Revista Española de Enfermedades Digestivas, ISSN-e 2340-4167, ISSN 1130-0108, Vol. 108, Nº. 12, 2016, págs. 780-784
• Idioma: inglés
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• Resumen

  • Background and aims: To assess the expression levels of cathepsins in malignant and premalignant lesions.

    Methods: We retrospectively included patients who underwent pancreatic surgery on pancreatic solid or cystic masses. The expression of cathepsin H, L, B and S was determined in both types of samples. Lesions were divided into three categories: malignant (pancreatic adenocarcinoma and malignant mucinous neoplasms), premalignant (mucinous neoplasms) and benign (other lesions).

    Results: Thirty-one surgical resection samples were studied.

    The expression of cathepsins was significantly higher in malignant lesions than in premalignant and benign lesions (H 75%, 27%, 37% p = 0.05; L 92%, 36%, 37% p = 0.011; B 83%, 36%, 62% p = 0.069; S 92%, 36%, 25% p = 0.004, respectively).

    Conclusions: Cathepsins are overexpressed in histological samples of malignant lesions compared to premalignant and benign lesions. However, the expression of cathepsins is similar in both premalignant and benign lesions.