Resumen de Sibship Analysis Based on Parental Genotype Reconstruction from Any Number of Reference Siblings
Previous analyses of alleged siblings have calculated the conditional probability of a test sibling ’s genotype given a referencesibling’s genotype; however, more genetic information is available when two or more reference siblings are tested. Based on the root conceptof identity by descent (IBD), we present a sibship method of parental genotype reconstruction (PGR) that can use any number of reference sibs.Nine PGR patterns, along with their respective IBD proportions of full-sibs and half-sibs, were identified and used to calculate joint sibship probabilities and likelihood ratio formulas. In addition, a correction PGR was developed for situations involving the same genotype repeatingin the reference sibs. The method is simple and can be applied to any number of alleged full or half-siblings.
