Sibship Analysis Based on Parental Genotype Reconstruction from Any Number of Reference Siblings
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Jian Huang [1] ; YuSong Huang [2]
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[1] Department of Forensic genetics Brains hospital of Hunan province Changsha China
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[2] Han‐5 Biological Engineering (Changsha) Co., Ltd Changsha China
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- Localización: Journal of forensic sciences, ISSN-e 1556-4029, ISSN 0022-1198, Vol. 62, Nº. 1, 2017, págs. 233-238
- Idioma: inglés
- Texto completo no disponible (Saber más ...)
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Resumen
Previous analyses of alleged siblings have calculated the conditional probability of a test sibling ’s genotype given a referencesibling’s genotype; however, more genetic information is available when two or more reference siblings are tested. Based on the root conceptof identity by descent (IBD), we present a sibship method of parental genotype reconstruction (PGR) that can use any number of reference sibs.Nine PGR patterns, along with their respective IBD proportions of full-sibs and half-sibs, were identified and used to calculate joint sibship probabilities and likelihood ratio formulas. In addition, a correction PGR was developed for situations involving the same genotype repeatingin the reference sibs. The method is simple and can be applied to any number of alleged full or half-siblings.
