Resumen de Architecture of the Pol III–clamp–exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair

Ana Toste Rêgo, Andrew N. Holding, Helen Kent, Meindert H. Lamers

• Chemical crosslinking coupled with mass spectrometry to structurally map the core bacterial replicase reveals the proofreading subunit to modulate DNA clamp interactions with the catalytic subunit and alternative translesion synthesis polymerases.