Architecture of the Pol III–clamp–exonuclease complex reveals key roles of the exonuclease subunit in processive DNA synthesis and repair

• Ana Toste Rêgo ^[1] ; Andrew N Holding ^[1] ; Helen Kent ^[1] ; Meindert H Lamers ^[1]
  1. [1] MRC Laboratory of Molecular Biology

     MRC Laboratory of Molecular Biology

     Cambridge District, Reino Unido

     
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 32, Nº. 9, 2013, págs. 1334-1343
• Idioma: inglés
• Enlaces
  • Texto completo
• Resumen

  • Chemical crosslinking coupled with mass spectrometry to structurally map the core bacterial replicase reveals the proofreading subunit to modulate DNA clamp interactions with the catalytic subunit and alternative translesion synthesis polymerases.