Resumen de Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains

Sviatoslav N Bagriantsev, Kimberly A Clark, Daniel L Minor

• The two-pore domain potassium channel K2P2.1 (TREK-1) responds to extracellular and intracellular stimuli, including pH and temperature. This study elucidates how the intracellular sensor element relays metabolic and thermal stimuli to the extracellular C-type gating element.