Metabolic and thermal stimuli control K2P2.1 (TREK-1) through modular sensory and gating domains

• Sviatoslav N Bagriantsev ^[1] ; Kimberly A Clark ^[1] ; Daniel L Minor ^[2]
  1. [1] Cardiovascular Research Institute, University of California, San Francisco, CA, USA
  2. [2] Cardiovascular Research Institute, University of California, San Francisco, CA, USA; Department of Biochemistry and Biophysics, and Cellular and Molecular Pharmacology, Cardiovascular Research Institute, University of California, San Francisco, CA, USA; California Institute for Quantitative Biomedical Research, University of California, San Francisco, CA, USA; Physical Biosciences Division, Lawrence Berkeley National Laboratory, Berkeley, CA, USA
• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 15, 2012, págs. 3297-3308
• Idioma: inglés
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• Resumen

  • The two-pore domain potassium channel K2P2.1 (TREK-1) responds to extracellular and intracellular stimuli, including pH and temperature. This study elucidates how the intracellular sensor element relays metabolic and thermal stimuli to the extracellular C-type gating element.