Resumen de Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation

Catherine Wilson, Catriona Crombie, Louise van der Weyden, George Poulogiannis, Alistair G. Rust, Mercedes Pardo, Tannia Gracia, Lu Yu, Jyoti Choudhary, Gino B Poulin, Rebecca E McIntyre, Douglas J Winton, H Nikki March, M. J. Arends, Andrew G. Fraser, David J. Adams

• Arising from a ras-interaction screen in C. elegans, nuclear receptor binding protein 1 (NRBP1) is shown to impose a crypt progenitor phenotype in mice and is proposed as a novel tumour suppressor in human cancer.