Nuclear receptor binding protein 1 regulates intestinal progenitor cell homeostasis and tumour formation

• Catherine H Wilson ^[1] ; Catriona Crombie ^[1] ; Louise van der Weyden ^[1] ; George Poulogiannis ^[3] ; Alistair G Rust ^[1] ; Mercedes Pardo ^[1] ; Tannia Gracia ^[1] ; Lu Yu ^[1] ; Jyoti Choudhary ^[1] ; Gino B Poulin ^[4] ; Rebecca E McIntyre ^[1] ; Douglas J Winton ^[5] ; H Nikki March ^[5] ; Mark J Arends ^[2] ; Andrew G Fraser ^[6] ; David J Adams ^[1]
  1. [1] Wellcome Trust Sanger Institute

     Wellcome Trust Sanger Institute

     Cambridge District, Reino Unido

     
  2. [2] University of Cambridge

     University of Cambridge

     Cambridge District, Reino Unido

     
  3. [3] Beth Israel Deaconess Medical Center

     Beth Israel Deaconess Medical Center

     City of Boston, Estados Unidos

     
  4. [4] University of Manchester

     University of Manchester

     Reino Unido

     
  5. [5] Cancer Research UK Cambridge Research Institute, Cambridge, UK
  6. [6] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK; The Donnelly Centre, University of Toronto, Toronto, Canada

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 11, 2012, págs. 2486-2497
• Idioma: inglés
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• Resumen

  • Arising from a ras-interaction screen in C. elegans, nuclear receptor binding protein 1 (NRBP1) is shown to impose a crypt progenitor phenotype in mice and is proposed as a novel tumour suppressor in human cancer.