Resumen de Novel repressor regulates insulin sensitivity through interaction with Foxo1

Jun Nakae, Yongheng Cao, Fumihiko Hakuno, Hiroshi Takemori, Yoshinaga Kawano, Risa Sekioka, Takaya Abe, Hiroshi Kiyonari, Yoshiya Tanaka, Juro Sakai, Shin-Ichiro Takahashi, Hiroshi Itoh

• This study characterizes a novel Foxo1 CoRepressor (FCoR) that regulates insulin sensitivity and energy metabolism as revealed by whole-body knockout. As target of PKA phosphorylation, FCoR modulates Foxo's acetylation known to control Foxo's biological activity.