Novel repressor regulates insulin sensitivity through interaction with Foxo1

• Jun Nakae ^[1] ; Yongheng Cao ^[2] ; Fumihiko Hakuno ^[3] ; Hiroshi Takemori ^[4] ; Yoshinaga Kawano ^[1] ; Risa Sekioka ^[1] ; Takaya Abe ^[5] ; Hiroshi Kiyonari ^[5] ; Toshiya Tanaka ^[3] ; Juro Sakai ^[3] ; Shin-Ichiro Takahashi ^[3] ; Hiroshi Itoh ^[1]
  1. [1] Keio University

     Keio University

     Japón

     
  2. [2] Kobe University

     Kobe University

     Chuo-ku, Japón

     
  3. [3] University of Tokyo

     University of Tokyo

     Japón

     
  4. [4] National Institute of Biomedical Innovation, Health and Nutrition

     National Institute of Biomedical Innovation, Health and Nutrition

     Japón

     
  5. [5] RIKEN Center for Developmental Biology

     RIKEN Center for Developmental Biology

     Chuo-ku, Japón

     

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• Localización: EMBO journal: European Molecular Biology Organization, ISSN 0261-4189, Vol. 31, Nº. 10, 2012, págs. 2275-2295
• Idioma: inglés
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• Resumen

  • This study characterizes a novel Foxo1 CoRepressor (FCoR) that regulates insulin sensitivity and energy metabolism as revealed by whole-body knockout. As target of PKA phosphorylation, FCoR modulates Foxo's acetylation known to control Foxo's biological activity.